LAB of  Diabetes and Metabolism 

1. Bae, S. S., Perry, D. K., Oh, Y. S., Choi, J. H., Galadari, S. H., Ghayur, T., Ryu, S. H., Hannun, Y. A., Suh, P. G.* (2000) Proteolytic cleavage of phospholipase C-g1 during apoptosis in Molt-4 cells. FASEB J. 9, 1083-1092.

 

2. Bae, S. S., Choi, J. H., Oh, Y. S., Perry, D. K., Ryu, S. H., Suh, P. G.* (2001) Proteolytic cleavage of epidermal growth factor receptor by caspases. FEBS Lett. 491, 16-20.

 

3. Bae, S. S., Choi, J. H., Oh, Y. S., Yun, S., Ryu, S. H., Suh, P. G. (2002) Regulation of phospholipase C-g1 by protein kinase A. Adv. Biol. Regul. 42, 195-211.

 

4. Choi, J. H., Bae, S. S., Park, J. B., Ha, S. H., Song, H., Kim, J. H., Cocco, L., Ryu, S. H., Suh, P. G. (2003) Cbl competitively inhibits epidermal growth factor-induced activation of phospholipase C-g1. Molecular & Cells 15, 245-255.

 

5. Choi, J. H., Hong, W. P., Kim, M. J., Kim, J. H., Ryu, S. H., Suh, P. G. (2004) Sorting nexin (SNX) 16 regulates epidermal growth factor receptor (EGFR) trafficking through its PX-domain-mediated interaction with phosphatidylinositol-3-phosphate (PtdIns (3) P). Journal of Cell Science 117, 4209-4218.

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6. Choi, J. H., Park, J. B., Bae, S. S., Yun, S., Kim, H. S., Hong, W. P., Kim, I. S., Han, M. Y., Ryu, S. H., Patterson, R. L., Snyder, S. H., Suh, P. G. (2004) Phospholipase C-g1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis. Journal of Cell Science 117, 3785-3795.

 

7. Chang, J. S., Kim, S. K., Kwon, T. K., Bae, S. S., Min, D. S., Lee, Y. H., Kim, S. O., Seo, J. K., Choi, J. H., Suh, P. G. (2005) Pleckstrin homology domains of phospholipase C-g1 directly interact with beta-tubulin for activation of phospholipase C-g1 and reciprocal modulation of beta-tubulin function in microtubule assembly. J. Biol. Chem. 280, 6897-6905.

 

8. Choi, J. H., Hong, W. P., Yun, S., Park, J. B., Ryu, S. H., Suh, P. G. (2005) Grb2 negatively regulates epidermal growth factor-induced phospholipase C-g1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-g1. Cellular Signaling 17, 1289-1299.

 

9. Kim, H. S., Yumkham, S., Choi, J. H., Lee, S. H., Kim, T. H., Ryu, S. H., Suh, P. G. (2006) Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgamma. Neuropeptides 40, 221-229.

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10. Kim, H. S., Yumkham, S., Choi, J. H., Kim, E. K., Kim, Y. S., Ryu, S. H., Suh, P. G. (2006) Haloperidol Induces Calcium Ion Influx Via L-Type Calcium Channels in Hippocampal HN33 Cells and Renders the Neurons More Susceptible to Oxidative Stress. Molecular & Cells 22, 51-57.

 

11. Kim, H. S., Yumkham, S., Choi, J. H., Son, G. H., Kim, K., Ryu, S. H., Suh, P. G. (2006) Serotonin stimulates GnRH secretion through the Src-PLCgamma1 pathway in GT1-7 hypothalamus cells. J. Endocrinol. 190, 581-591.

 

12. Kim, S. K., Choi, J. H., Suh, P. G., Chang, J. S. (2006) Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain. Exp. Mol. Med. 38, 265-272.

 

13. Kim, H. S., Song, M., Yumkham, S., Choi, J. H., Lee, T. H., Kwon, J., Lee, S. J., Kim, J. I., Lee, K. W., Han, P. L., Shin, S. W., Baik, J. H., Kim, Y. S., Ryu, S. H., Suh, P. G.* (2006) Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid. J. Neurochem. 99, 458-469.

 

14. Choi, J. H., Kim, H. S., Kim, S. H., Yang, Y. R., Bae, Y. S., Ryu, S. H., Suh, P. G. (2006) Phospholipase C-g1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B. Nature Cell Biology 8, 1389-1397.

 

15. Kim, S. K., Cho, S. M., Lee., I. B., Lee, Y. H., Kang. J. H., Choi, J. H., Suh, P. G., Chang, J. S. (2007) In vitro assay of neurofilament light chain self-assembly using truncated mutants. J. Neuro. Methods. 161, 199-204.

 

16. Choi, J. H., Yang, Y. R., Lee, S. K., Kim, I. S., Ha, S. H., Kim, E. K., Bae Y. S., Ryu, S. H., Suh, P. G. (2007) Phospholipase C-g1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation. Cellular Signalling 19, 1784-1796.

 

17. Choi, J. H., Ryu, S. H., Suh, P. G. (2007) On/Off regulation of phospholipase C-g1-mediated signaling pathway. Adv. Biol. Regul. 47, 104-116.

 

18. Heo, S. K., Yoon, M. A., Lee, S. C., Ju, S. A., Choi, J. H., Suh, P. G., Kwon, B. S., Kim, B. S. (2007) HVEM signaling in monocytes is mediated by intracellular calcium mobilization. J. Immunol. 179, 6305-6310.

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19. Mian, M. F., Kang, C., Lee, S., Choi, J. H., Bae, S. S., Kim, S. H., Kim, Y. H., Ryu, S. H., Suh, P. G., Kim, J. S., Kim, E. (2008) Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem. Biol. Interact. 171, 57-66.

 

20. Yun, S., Hong, W. P., Choi, J. H., Yi, K. S., Chae, S. K., Ryu, S. H., Suh, P. G. (2008) Phospholipase C-e augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation. J. Biol. Chem. 283, 341-349.

 

21. Choi, J. H., Yang, Y. R., Lee, S. K., Kim, S. H., Kim, Y. H., Cha, J. Y., Oh, S. W., Ha, J. R., Ryu, S. H., Suh, P. G. (2008) Phenothiazines specifically inhibited PDK-1/Akt-mediated signaling pathway. Ann. N Y Acad. Sci. 1138, 393-403.

 

22. Choi. J. H., Banks, A. S., Estall, J. L., Kajimura, S., Bostrom, P., Laznik, D., Ruas, J. L., Chalmers, M. J., Kanemnecka, T. M., Bluher, M., Griffin, P. R., Spiegelman, B. M. (2010) Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARg by cdk5. Nature 466, 451-456.

 

23. Wu, J., Ruas, J. L., Estall, J. L., Rasbach, K., Choi, J. H., Ye, L., Campbell. K. P., Rutlowski, D. T., Kaufman, R. J., Spiegelman, B. M. (2011) The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex. Cell Metabolism 13, 160-169.

 

24. Lustig, Y, Ruas, J. L., Estall, J. L., Lo, J. C., Devarakonda, S., Laznik, D., Choi, J. H., Ono, H., Olsen, J. V., Spiegelman, B. M. (2011) Separation of the Gluconeogenic and Mitochondrial Functions of PGC-1α through S6 Kinase. Genes & Development 25, 1232-1244.

 

25. Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin,, Y., He, Y., Bruning, J. B., Marciano, D., Cameron, M. D., Laznik, D., Jurczak, M. J., Schurer, S. C., Vidovic, D., Shulman, G. I., Spiegelman, B. M. and Griffin, P. R. (2011) Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477, 477-481.

 

26. Bhalla, K., Hwang, B. J., Choi, J. H., Dewi, R., Ou, L., Twaddel, W., Mclenithan, J., Voronkov, M., Pozharskiy, E., Girnun, G. (2011) N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo. J. Biol. Chem. 286, 41626-41635.

 

27. Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., Kajimura, S., Zingaretti, M. C., Vind, B. F., Tu, H., Cinti, S., Højlund, K., Gygi, S. P., Spiegelman, B. M. (2012) A PGC1α-dependent myokine that drives browning of white fat and thermogenesis. Nature 481, 463-468.

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28. Malapaka, R. V., Khoo, S. K., Zhang, J., Choi. J. H., Zhou, X. E., Xu, Y., Chalmers, M. J., Chang, L., Resau, J. H., Griffin, P. R., Chen, Y. E. Xu, H. E. (2012) Identification and Mechanism of a Ten Carbon Fatty Acid as a Natural Modulating Ligand of Peroxisome Proliferator–Activated Receptors. J. Biol. Chem. 287, 183-195.

 

29. Yang, Y. R., Choi, J. H., Chang, J. S., Kwon, H. M., Jang, H. J., Ryu, S. H., Suh, P. G. (2013) Diverse cellular and physiological roles of phospholipase C-γ1. Adv. Biol. Regul. 52, 138-151.

 

30. Dutchak, P. A., Katafuchi, T., Bookout, A, L., Choi J. H., Mangelsdorf, D. J., Kliewer, S. A. (2012) Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones. Cell 148, 556-567.

 

31. Kim, J. K., Kwon, O., Kim, J., Kim, E. K., Park, H. K., Lee, J. E., Kim, K. L., Choi, J. W., Lim, S., Seok, H., Lee-Kwon, W., Choi, J. H., Kang, B. H., Kim, S., Ryu, S. H., Suh, P. G. (2012) PDZ domain-containing 1 (PDZK1) regulates phospholipase C-β3 (PLC-β3) specific activation of somatostatin by forming a ternary complex with PLC-β3 and somatostatin receptors. J. Biol. Chem. 287, 21012-21024.

 

32. Yang, Y. R., Song, M., Lee, H., Jeon, Y., Choi, E. J., Jang, H. J., Moon, H. Y., Byun, H. Y., Kim, E. K., Kim, D. H., Lee, M. N., Koh, A., Ghim, J., Choi, J. H., Lee-Kwon, W., Kim, K. T., Ryu, S. H., Suh, P. G. (2012) O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell 11, 439-448.

 

33. Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerbäck, S., Schrauwen, P., Spiegelman, B. M. (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376.

 

34. Moon, H. Y., Kim, S. H., Yang, Y. R., Song, P., Yu, H. S., Park, H. G., Hwang, O., Lee-Kwon, W., Seo, J. K., Hwang, D., Choi. J. H., Bucala, R., Ryu, S. H., Kim, Y. S., Suh, P. G. (2012) Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc. Natl. Acad. Sci. U S A. 109, 13094-13099.

 

35. Hwang, S. L., Kwon, O., Lee, S. J., Roh, S. S., Kim, Y. D., Choi. J. H. (2012) B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB. Biochem. Biophys. Res. Commun. 427, 801-805.

 

36. Jang, H. J., Yang, Y. R., Kim, J. K., Choi. J. H., Seo, Y. K., Lee, Y. H., Lee, J. E., Ryu, S. H., Suh, P. G. (2013) Phospholipase C-γ1 involved in brain disorders. Adv. Biol. Regul. 53, 51-62.

 

37. Koh, A., Lee, M. N., Yang, Y. R., Jeong, H., Ghim, J., Noh, J., Kim, J., Ryu, D., Park, S., Song, P., Koo, S. H., Leslie, N. R., Berggren, P. O., Choi, J. H., Suh, P. G., Ryu, S. H. (2013) C1-Ten is a Protein Tyrosine Phosphatase of IRS-1, Regulating IRS-1 Stability and Muscle Atrophy. Mol. Cell. Biol. 33, 1608-1620.

 

38. Koh, M., Park, J., Koo, J. Y., Lim, D., Cha, M. Y., Jo, A., Choi, J. H., Park, S. B. (2014) Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy. Angew. Chem. Int. Ed. Engl. 53, 5102-5106.

 

39. Yang, Y. R., Jang, H. J., Yoon, S., Lee, Y. H., Nam, D., Kim, I. S., Lee, H., Kim, H., Choi, J. H., Kang, B. H.,  Ryu, S. H., Suh, P. G. (2014) OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice. Oncogenesis 3, e109.

 

40. Choi, S. S., Kim, E. S., Koh, M., Lee, S. J., Lim, D., Yang, Y. R., Jang, H. J., Seo, K. A., Min, S. H., Lee, I. H., Park, S. B., Suh, P. G., Choi, J. H. (2014) A novel non-agonist PPARγ ligand UHC1 blocks PPARγ phosphorylation by CDK5 and improves insulin sensitivity. J. Biol. Chem. 289, 26618-26629.

 

41. Choi, J. H.*, Choi, S. S., Kim, E. S., Jedrychowski, M. P., Yang, Y. R., Jang, H. J., Suh, P. G.,  Banks, A. S., Gygi, S. P, Spiegelman, B. M.* (2014) Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming. Genes & Development 28, 2361-2369. * Co-corresponding authors

 

42. Choi, S. S., Park, J., Choi, J. H. (2014) PPARγ as a revisiting target for treatment of metabolic disorders. BMB Reports 47, 599-608.

 

43. Choi, J. S., Choi, S. S., Kim, E. S., Seo, Y. K., Seo, J. K., Kim, E. K., Suh, P. G., Choi, J. H. (2015) Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα. Cellular Signalling 27, 614-620.

 

44. Yang, Y. R., Kim, D. H., Seo, Y. K., Park, D., Jang, H. J., Choi, S. Y., Lee, Y. H., Lee, G. H., Nakajima, K., Taniguchi, N., Kim, J. M., Choi, E. J., Moon, H. Y., Kim, I. S., Choi, J. H., Lee, H., Ryu, S. H., Cocco, L., Suh, P. G. (2015) Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling. Oncotarget 6, 12529-12542.

 

45. Yang, Y. R., Jang, H. J., Choi, S. S., Lee, Y. H., Lee, G. H., Seo, Y. K., Choi, J. H., Park, D., Koh, A., Kim, I. S., Lee, H., Ryu, S. H., Suh, P. G. (2015) Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice. Diabetologia 58, 2867-2876.

 

46. Choi, S., Jung, J. E., Yang, Y. R., Kim, E. S., Jang, H. J., Kim, E. K., Kim, I. S., Lee, J. Y., Kim, J. K., Seo, J. K., Kim, J. M., Park, J., Suh, P. G., Choi, J. H. (2015) Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity. Cellular Signaling 27, 2488-2495.

 

47. Choi, S., Kim, E. S., Jung, J. E., Marciano, D. P., Jo, A., Koo, J. Y., Choi, S. Y., Yang, Y. R., Jang, H. J., Kim, E. K., Park, J., Kwon, H. M., Lee, I. H., Park, S. B., Myung, K. J., Suh, P. G., Griffin, P. R., Choi, J. H. (2016) PPARγ antagonist Gleevec improves insulin sensitivity and promotes the browning of white adipose tissue. Diabetes 65, 829-839.

 

48. Bae, W., Jang, J. Y., Choi, S., Lee, J., Kim, H., Jo, A., Lee, K. J., Choi, J. H., Suh, S. W., Park, S. B. (2016) Mechanistic elucidation  guided by covalent inhibitors for the development of anti-diabetic PPARg ligands. Chem. Sci. 7, 5523-5529.

 

49. Yang, Y. R., Jung, J. H., Kim, S. J., Hamada, K., Suzuki, A., Kim, H. J., Lee, J. H., Kwon, O. B., Lee, Y. K., Kim, J., Kim, E. K., Jang, H. J., Kang, D. S., Choi, J. S., Lee, C. J., Marshall, J., Koh, H. Y., Kim, C. J., Seok, H., Kim, S. H., Choi, J. H., Choi, Y. B., Cocco, L., Ryu, S. H., Kim, J. H., Suh, P. G. (2017) Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. Mol. Psychiatry. 22, 1473-1482.

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50. Khandekar MJ., Bacnks AS., Laznik-Bogoslavki D., White JP., Choi, J. H., Kazak L., Lo JC., Cohen P., Wong KK., Kamenecka TM., Griffin PR., Spiegelman BM. (2018) Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc. Natl. Acad. Sci. U S A. 115, 561-566.

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51. Park, J. E., Lee, E. J., Kim, J. K., Song, Y., Choi, J. H., Kang, M. J. (2018) Flightless-I Controls Fat Storage in Drosophila. Mol. Cells 41, 603-611.

 

52. Shin, Y., Kim, Y. W., Kim, H., Shin, N., Kim, T. S., Kwon, T. K., Choi, J. H., Chang, J. S. (2018) RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2. Biomed. Rep. 9, 241-246.

 

53. Hwang, H. J., Park, K. S., Choi, J. H., Cocco, L., Jang, H. J., Suh, P. G. (2018) Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels. J. Cell. Physiol. 233, 8701-8710.

 

54. Lee, J. M., Choi, S. S., Lee, Y. H., Khim, K. W., Yoon, S., Kim, B., Nam, D., Suh, P. G., Myung, K., Choi, J. H. (2018) The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ. Exp. Mol. Med. 50, 135-146.

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55. Lee, C., Kim, M., Lee, J. H., Oh, J., Shin, H. H., Lee, S. M., Scherer, P. E., Kwon, H. M., Choi, J. H., Park, J. (2019) COL6A3‐derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease. J. Path. 247, 99-109.

 

56. Kim, H., Jo, A., Choi, S. S., Nam, H., Byun, W. G., Bae, H., Choi, J. H., Park, S. B. (2018) Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation. Asian J. Org. Chem.

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57. Hua, T. N. M., Kim, M. K., Vo, V. T. A., Choi, J. W., Choi, J. H., Kim, H. W., Cha, S. K., Park, K. S., Jeong, Y. (2019) Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression. EBioMedicine 41, 134-145.

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58. Hwang, H. J., Yang, Y. R., Kim, H. Y., Choi, Y., Park, K. S., Lee, H., Ma, J. S., Yamamoto, M., Kim, J., Chae, Y. C., Choi, J. H., Cocco, L., Berggren, P. O, Jang, H. J., Suh, P. G. (2019) Phospholipase C-β1 potentiates glucose-stimulated insulin secretion. FASEB J. 33, 10668-10679.

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59. Jang, H. J., Lim, S., Kim, J. M., Yoon, S., Lee, C. Y., Hwang, H. J., Shin, J. W., Shin, K. J., Kim, H. Y., Nam, D., Yea, K., Hirabayashi, Y., Lee, Y. J., Chae, Y. C., Suh, P. G., Choi, J. H. (2020) Glucosylceramide synthase is a molecular switch of adipo-osteogenic balance through synergistic activation of PPARγ with GlcCer. FASEB J. 34, 1270-1287.

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60. Khim, K. W., Choi, S. S., Jang, H. J., Lee, Y. H., Lee, E., Hyun, J. M., EomH. J., Yoon, S., Choi, J. W., Park, T. E., Nam, D., Choi, J. H. (2020) PPM1A controls diabetic gene programming through directly dephosphorylating PPARγ at Ser273. Cells 9, 343.

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61. Lee, J. M., Choi, S. S., Park, M. H., Jang, H., Lee, Y. H., Khim, K. W., Oh, S. R., Park, J., Ryu, H. W., Choi, J. H. (2020) Broussonetia papyrifera root bark and its bioactive compounds suppress adipose tissue inflammation and ameliorate insulin resistance via AMPK activation. Nutrients 12, 773.

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62. Choi, S. S., Lee, S. K., Kim, J. K., Park, HK., Lee, E., Jang, J., Lee, Y. H., Khim, K. W., Hyun, JM., Eom, HJ., Lee, S., Kang, B. H., Chae, Y. C., Myung, K., Myung, SJ., Park, C. Y., Choi, J. H. (2020) Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis. Exp. Mol. Med. 52, 940-950.

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63. Ju, M. K.†, Shin, K. J.†, Lee, J. R.†, Khim, K.W.†, Lee, EA., Ra, J. S., Kim, BG., Jo, H., Yoon, J. H., Kim, T. M., Myung, K., Choi, J. H.*, Kim, H.*, Chae, Y. C.* (2021) NSMF promotes the replication stress-induced DNA damage response for genome maintenance. Nucleic Acids Res. 49(10). 5605-5622.

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64. Hyun, J.†, Park, M. H.†, Lee, Y. H.†, Lee, Y., Jeong, S. J., Choi, S. S., Khim, K. W., Eom, HJ., Hur, J-H., Park, C. Y., Kim, J-I., Park, J., Ryu, H. W., Jang, H. J.*, Oh, S. R.*, Choi, J. H.* (2021) Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic β-cells and improves insulin sensitivity in diabetic mice. J. Ethnopharmacol. 278, 114238.

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65. Kang, H. J.†, Eom, HJ.†, Kim, H., Myung, K., Kwon, H. M.*, Choi, J. H.* (2021) Thrap3 promotes R-loop resolution via interaction with methylated DDX5. Exp. Mol. Med. 53, 1602-1611.

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66. Lee, Y. H.†, Jang, H. J.†, Kim, S.†, Choi, S. S., Khim, K. W., Eom, HJ., Hyun, J., Shin, K. J., Chae, Y. C., Kim, H., Park, J., Park, N. H., Woo, CY., Hong, C. H., Koh, E. H., Nam, D.*, Choi, J. H*. (2021) Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA. eLife 11:e70472.

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67. Kwon, T.†, Ra, J. S.†, Lee, S.†, Baek, IJ.†, Khim, K. W., Lee, E. A., Song, E. K., Oarbayev, D., Jung, W., Park, Y. H., Wie, M., Bae, J., Cheng, H., Park, J. H., Kim N., Seo, Y., Yun, S., Kim, H. E., Moon, H. E., Paek, S. H., Park, T. J., Park, Y. U., Rhee, H., Choi, J. H., Cho, S. W.*, Myung K.* (2022) Precision tumor cell death through targeting cancer-specific InDel mutations with CRISPR-Cas9. Proc. Natl. Acad. Sci. U.S.A. 119 (9), e2103532119

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68. Jang, HJ.†, Lee, Y.H.†, Dao, T., Jo, Y., Khim, K.W., Eom, Hj., Lee, J.E., Song, Y.J., Choi, S.S., Park, K., Ji, H., Chae, Y.C., Myung, K., Kim, H., Ryu, D., Park, N.H., Park, S.H.*, Choi, J. H.* (2023) Thrap3 promotes non-alcoholic fatty liver disease by suppressing AMPK-meadiated autophagy. Exp. Mol. Med. 55, 1720-1733.

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69. Kang, Y., Han, Y.G., Khim, K.W., Choi, W.G., Ju, M.K., Park, K., Shin, K.J., Chae, Y.C., Choi, J. H.*, Kim, H.*, Lee, J.Y.* (2023) Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase. Nucleic Acids Res. gkad543

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70. Wie, M.†, Khim, K.W.†, Groehler IV, A.S., Heo, S., Woo, J., Son, K., Lee E.A., Ra, J.S., Hong, S.Y., Scharer, O.D., Choi, J. H.*, Myung, K.* (2023) Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors. NAR Cancer. zcad042